Jon Hamm is Sergio!
This is a funny Saturday Night Live Digital Short which features Mad Men star and frequent SNL visitor Jon Hamm.
A suit portrayed by Andy Samberg accidentally crushes a homeless Indian guy’s talisman played by Fred Armisen and then he refuses to pay for it. The homeless person then hexes Samberg and whenever he does something, an oily, mystical, and saxophone-playing being rises out of nowhere to disturb Samberg.
I got the clip from Funny or Die.